2007 Publications

Cohen MZ, Slomka J, Pentz RD, Flamm A, Gold D, Herbst R, Abbruzzese JL Phase I participants' views of quality of life and trial participation burdens. Supportive Care in Cancer. Published online January 25, 2007.
Click for Abstract

Yuan, J-M., Gao, Y-T., Yang, C.S., and Yu, M.C. Urinary biomarkers of tea
polyphenols and risk of colorectal cancer in the Shanghai cohort study. Inter. J. Cancer 120: 1344-1350, 2007.
Click for Abstract

Lambert, J.D., Sang, S., and Yang, C.S. Possible controversy over dietary polyphenols: benefits vs risks. Chem. Res. Toxicol. 20: 583-585, 2007.
Click for Abstract

Yang, C.S., Lambert, J.d., Ju, J., Lu, G., and Sang, S. Tea and cancer prevention: molecular mechanisms and human revelance. Toxicol. Appl. Pharmacol. (Published on-line), 2007.
Click for Abstract

Zhang, X., Hunt, J., Shin, D. M., Chen, Z (G). Down Regulation of S100A2 in Lymph Node Metastases as Compared to Non-metastatic Primary Tumors in Head and Neck Cancer. Head and Neck, 29:236-243, 2007.
Click for Abstract

Zhang, X., Chen, Z (G)., Y., Wieand, S., Shin, D. M. A combined treatment with 13-Cis-Retinoid Acid, Interferon- a 2a and a -Tocopherol induces cell cycle arrest and apoptosis in squamous carcinoma cells of the head and neck cancer. Head and Neck, 29:351-361, 2007.
Click for Abstract

Choe, M. S., Chen, Z(G)., Carmen Klass, Zhang, X., Lee, J., Shin, D. M. (2007) Enhancement of docetaxel-induced cytotoxicity by blocking EGFR and COX-2 pathways in squamous cell carcinoma of the head and neck. Clinical Cancer Res, 13:3015-3023.
Click for Abstract

Jung CS, Zhou Z, Fadlo KR, Sun S-Y. Assessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells. Cancer Biol Ther, 2007 May 7;6(5) [Epub ahead of print].
Click for Abstract

Zhang Q, Bhola NE, Lui VWY, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin DM, Rubin, Grandis J. Antitumor mechanisms of combined GRPR and EGFR targeting in head and neck cancer. Mol Cancer Ther 6(4):1414-1424, 2007.
Click for Abstract

Jung CS, Zhou Z, Khuri FR, Sun SY. Assessment of apoptosis-inducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells. Cancer Biology and Therapeutics. May 7;6(5) [Epub ahead of print] 2007.
Click for Abstract

Shigemura K, Arbiser JL, Sun SY, Zayzafoon M, Johnstone PA, Fujisawa M, Gotoh A, Weksler B, Zhau HE, Chung LW. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Cancer. 2007 Feb 26; [Epub ahead of print].
Click for Abstract

Yang L , Lin C, Sun S-Y, Liu ZR. A double tyrosine phosphorylation of p68 RNA helicase confers resistance to TRAIL-induced apoptosis. Oncogene, 2007 Mar 26; [Epub ahead of print].
Click for Abstract

Zou W, Liu X, Yue P, Khuri RK, Sun SY. PPAR ligands enhance TRAIL-induced apoptosis through DR5 upregulation and c-FLIP downregulation in human lung cancer cells. Cancer Biol Ther, 2007 Jan 29;6(1) [Epub ahead of print]

Asif, G., Hurwitz, S.J., Obikhod A., Delinsky D., Narayanasamy J., Chu, C.K., McClure H.M., Schinazi, R.F. Pharmacokinetics of the Anti-HIV Agent b -D-Dioxolane-thymine in Rhesus Monkeys. Antimicrob. Agents & Chemother. In press, 2007.

Menne, S., Asif, G. Narayanasamy, J., Butler, S.D. George, A.l.. Hurwitz, S.J., Schinazi, R.F, Chu, .K., Cote, P.J., Gerin, J.L., Tennant, B.E. Antiviral effect of orally administered (-)-β-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents & Chemother. In press, 2007.

Saba NF , Khuri FR, Shin DM. Epidermal Growth Factor Receptor (from the bench to the clinic). An overview of trials in Head and Neck and Lung Cancer. (in press to Oncology).

Asif, G., Hurwitz, S.J. , Shi, J.S., Hernandez-Santiago, B.I., Schinazi, R.F. Pharmacokinetics of antiviral agent b -D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys. Antimicrob. Agents & Chemother. In press, 2007.

Yoon, Y., Liang, Z., Zhang, X., Choe, M., Cho, H. T., Shin, D. M., Goodman, M., Chen, Z(G)., Shim, H. CXCR4 antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. Cancer Res. In press, 2007.

He, Z.,Tang, F., Ermakova, S., Li, M., Zhao, D., Cho, Y-Y., Ma, W. Y., Choi, H. S., Bode, A. M., Yang, C. S., Dong, Z. Fyn is a novel target of (-) pigallocatechin gallate in the inhibition of JB6 C141 cell transformation. Molecular Carcinogenesis (in press), 2007.

Suh, N., Paul, S., Lee, H.J., Ji, Y., Lee, M-J., Yang, C.S., Reddy, B.S., and Newmark, H.L. Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats. Nutr. Cancer (accepted).

Hao, X., Bose, M., Lambert, J.D., Ju, J., Lu, G., Lee, M-J., Park, S., Husain, A., Wang, S., Sun, Y., Yang, C.S. Inhibition of tumorigenesis in ApcMin/+ mice by green tea polyphenols (polyphenon E) and individual catechins. Nutrition & Cancer (in press).

Yang, C.S., Sang, S., Yang, I., Ho, C-T. Autoxidative quinone formation in vitro and metabolite formation in vivo from tea polyphenol (-)-epigallocatechin-3- gallate: Studied by real-time 4 mass spectrometry combined with tandem mass ion mapping. Free Rad. Biol. Med. (in press.).

Pentz RD, Flamm AL, Sugarman J, Cohen MZ, Xu Z, Herbst RS, Abbruzzese JL. Who ought to go first in trials with scarce agents? The views of potential participants. IRB 2007 In press.

Zhiheng, X., Tighiouart, M., and Rogatko, A. EWOC 2.0: Interactive Software for Dose Escalation in Cancer Phase I Clinical Trials. Drug Information Journal, 41(2):221-228, 2007 .

Elrod HA, Lin Y-D, Yue P, Wang W, Lonial S, Khuri KR, Sun S-Y. Thealkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Mol Cancer Ther, in revision.

Qiu Y, Liu X, Yue P, Lonial S, Khuri RK, Sun S-Y. The farnesyltransferase inhibitor R115777 upregulates DR5 expression and enhances TRAIL-induced apoptosis in human lung cancer cells. Cancer Res, in press.

Liu XG, Yue P, Chen S, Hu L, Lonial S, Fadlo KR, Sun S-Y. The proteasome inhibitor PS-341 upregulates death receptor 5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite upregulation of c-FLIP and survivin in human lung cancer cells. Cancer Res, in press.

Sun S-Y , Liu X, Yue P, Zhou Z, Zou W, Marcus AI, Khuri FR. Farnesyltransferase inhibitors induce CHOP-dependent expression of death receptor 5 leading to induction of apoptosis in human cancer cells. J Biol Chem, in press.

Sun S-Y , H Fu, Khuri FR. Targeting mTOR signaling for lung cancer therapy. J Thor Oncol, 2007 in press.

McLean JN, Nunley SR, Klass C, Moore CE, Müller S, Johnstone PAS. Esthesioneuroblastoma: The Emory University Experience. Arch Otolaryngol (in press).

Saba NF , Shin DM, Khuri FR. Moving toward bioadjuvant approaches to head and neck cancer prevention. (in press) IJROBP, 2007.

Zinner RG, Nemunaitis J, Eeiseman IA, Donato N, Shin HJC, Olson SC, Christensen J, Huang X, Lenehan PF, Shin DM: Phase I clinical and pharmacodynamic evaluation of oral CI-1033 given daily for 7 days every 3 weeks in patients with refractory cancer. Clin Cancer Res (In press), 2007.