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Zhou LAB - Overview Wei Zhou, PhD - Principal Investigator Molecular Genetics of Human Cancer The tumor genome is a dynamic, unstable entity and constantly undergoes changes due to defects in the DNA repair and mitotic checkpoint machineries. Among the numerous genetic alterations in tumor cells, only a few events lead to the activation of oncogenes or the inactivation of tumor suppressor genes, both of which are essential for tumor development. Most genetic alterations in tumors are passenger mutations, and one of the greatest challenges in the field of cancer genetics is the identification of those specific mutations that spur tumorigenesis. We are interested in identifying such mutations for cancer diagnosis, prognosis and experimental therapy, using the latest genomic tools, such as gene expression profile analysis or single-nucleotide polymorphism analysis. |
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