Research

Selected Publications from Wei Zhou's Biosketch

1.      Zhou, W., Reines, D. and Doetsch, P.W.  T7 RNA Polymerase Bypass of Large Gaps on the Template Strand Reveals a Critical Role of the Nontemplate Strand in Elongation.  Cell. 1995. 82(4) 577-585.

2.      Velculescu, V.E., Zhang, L., Zhou, W., Vogelstein, J., Basrai, M.A., Bassett, D.E., Hieter, P., Vogelstein, B. and Kinzler, K.W.  Characterization of the Yeast Transcriptome.  Cell. 1997. 88(2) 243-251.

3.      Zhang, L.*, Zhou, W.* (equal contribution), Velculescu, V.E., Kern, S.E., Hruban, R.H., Hamilton, S.R., Vogelstein, B. and Kinzler, K.W.  Gene Expression Profiles in Normal and Cancer Cells.  Science. 1997. 276 1268-1272.

4.      Zhou, W., Sokoll, L.J., Bruzek, D.J., Zhang, L., Velculescu, V.E., Gordin, S.B., Hruban, R.H., Kern, S.E., Hamilton, S.R., Chan, D.W., Vogelstein, B. and Kinzler, K.W.  Diagnostic Markers for Pancreatic Cancer.  Cancer Epidemiol., Biomarkers & Prev. 1998. 7 109-112.

5.      Velculescu, V.E., Madden, S.L., Zhang, L., Lash, A.E., Yu, J., Rago, C., Lal, A., Wang, C.J., Beaudry, G.A., Ciriello, K.M., Cook, B.P., Dufault, M.R., Ferguson, A.T., Gao, Y.,He, T., Hermeking, H., Hiraldo, S.K., Hwang, P.M., Lopez, M.A., Luderer, H.F., Mathews,B., Petroziello, J.M., Polyak, K., Zawel, L., Zhang, W., Zhang, X., Zhou, W., Haluska, F.G., Jen, J., Sukumar, S., Landes, G.M., Riggins, G.J., Vogelstein, B. and Kinzler, K.W. Analysis of human transcriptomes.  Nature Genetics.  1999.  23(4), P 387-388.

6.      Zhou, W., Galizia, G., Goodman, S.N., Romans, K.E., Kinzler, K.W., Choti, M.A., Montgomery, E.A., Vogelstein, B.  Counting alleles reveals a connection between chromosome 18q loss and vascular invasion. Nature Biotechnology.  2001. 19(1), P78-81.

7.      Shih, I., Zhou, W., Goodman, S.N., Lengauer, C., Kinzler, K.W. and Vogelstein, B. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res. 2001 61(3), P818-22.

8.      Zhou, W., Goodman, S.N., Galizia, G., Lieto, E., Ferraraccio, F., Pignatelli, C., Purdie, C.A., Piris, J., Morris, R., Harrison, D.J., Paty, P.B., Culliford, A., Romans, K.E., Montgomery, E.A., Choti, M.A., Kinzler, K.W. and Vogelstein, B.  Counting alleles to predict recurrence of early stage colorectal cancers. The Lancet. 2002. 359, P219-225.

9.      Zhou, W. Mapping genetic alterations in tumors with single nucleotide polymorphisms. 2003. Curr Opin Oncol. 2003. 15, 50-54.

10.  Hunter, S. B., Brat, D. J., Olson, J. J., Von Deimling, A., Zhou, W., and Van Meir, E. G. Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy, Int J Oncol 2003, 23, 857-69.

11.  Yan, H. and Zhou, W. Allelic variations in gene expression. Curr Opin Oncol. 2004. 16, 39-43.

12.  Zhou, W., Goodman, M., Lyles, R.H., Lim, S.D., Williams, T.Y., Rusthoven, K.E., Mandel, J.S., Amin, M.B. and Petros, J.A.  Surgical Margin and Gleason Score As Predictors of Post-operative Recurrence in Prostate Cancer with or without Chromosome 8p Allelic Imbalance.  The Prostate. 2004, 15 (61), 81-91.

13.  Tan, C., de Noronha, R. G., Roecker, A. J., Pyrzynska, B., Khwaja, F., Zhang, Z., Zhang, H., Teng, Q., Nicholson, A. C., Giannakakou, P., Zhou, W., Olson, J. J., Pereira, M. M., Nicolaou, K. C., and Van Meir, E. G. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway, Cancer Res, 2005, 65, 605-12.

14.  Wang, Y., O'Brate, A., Zhou, W., and Giannakakou, P. Resistance to microtubule-stabilizing drugs involves two events: beta-tubulin mutation in one allele followed by loss of the second allele. Cell Cycle, 4: 1847-1853, 2005.

15.  Morikawa, A., Williams, T. Y., Dirix, L., Colpaert, C., Goodman, M., Lyles, R. H., Zhong, D., and Zhou, W. Allelic imbalances of chromosomes 8p and 18q and their roles in distant relapse of early stage, node-negative breast cancer. Breast Cancer Res, 7: R1051-1057, 2005.

16.  Karoui, N. E., Zhou, W., and Whittemore, A. S. Getting more from digital SNP data. Stat Med, 2006. online.

17.  Zhong, D., Morikawa, A., Guo, L., Colpaert, C., Xiong, L., Nassar, A., Chen, C., Lamb, N., Dong, J. T., and Zhou, W. Homozygous Deletion of SMAD4 in Breast Cancer Cell Lines and Invasive Ductal Carcinomas. Cancer Biol Ther, 5, 2006.

18.  Dong, X., Chen, C., Sun, X., Guo, P., Vessella, R.L., Wang, R., chung, W.K., Zhou, W., and Dong, J.  FOXO1A is a Candidate for the 13q14 Tumor Suppressor Gene Inhibiting AR Signaling in Prostate Cancer.  Cancer Res, 2006, in press.

19.  Zhong, D., Guo, L., de Aguirre, I., Liu, X., Lamb, N., Sun, S-Y, Gal, A., Vertino, P.M. and Zhou, W. LKB1 Mutation in Large Cell Carcinoma of the Lung. Lung Cancer, 2006, in press.